Taking Magnesium? Avoid These 5 Drugs and Other Supplements, Expert Says

February 18, 2026 - 03:42

Magnesium has surged in popularity as a go-to supplement for improving sleep, reducing muscle cramps, and supporting overall wellness. However, experts emphasize that to harness its benefits effectively and safely, users must be aware of significant interactions with common medications and other supplements.

A primary concern is the concurrent use of magnesium with certain antibiotics, specifically tetracyclines and quinolones. Magnesium can bind to these drugs in the digestive tract, severely impairing their absorption and reducing their effectiveness. Similar interference can occur with several osteoporosis medications, such as bisphosphonates, which should be taken at a different time of day.

Furthermore, individuals on specific heart medications, like digoxin, or certain diuretics, need to exercise caution. Magnesium can influence electrolyte balance and potentially alter how these drugs work. Even common over-the-counter supplements, particularly calcium and zinc, can compete with magnesium for absorption if taken simultaneously.

The consensus from health professionals is clear: timing and awareness are crucial. To maximize efficacy and minimize risks, they advise spacing the intake of magnesium and these interacting substances by at least two to four hours. Always consulting a healthcare provider before starting any new supplement regimen is the most important step for personalized and safe guidance.